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KMID : 1123920040180010265
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 1 p.265 ~ p.273
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Kami-bang-pung-tong-sung-san is Involved in Protecting Neuronal Cells from Cytotoxic Insults
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Na Young-Cheul
Namgung Uk
Lee Yong-Gu
Kim Dong-Hee
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Abstract
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KBPTS is the fortified prescription of Bang-pung-tong-sung-san (BPTS) by adding Spatholobi Clulis and Salviae Miltiorrzae Radix. BPTS prescription has been used in Qriental medicine for the treatments of vascular diseases including hypertension, stroke, and arteriosclerosis, and nervous system diseases. Yet, the overall mechanism underlying its activity at the cellular levels remains unknown. To investigate the protective role of KBPTS on brain functions, noxious stimulations were applied to neurons in vitro and in vivo. KBPTS pretreatment in cultured cortical neurons of albino ICR mice rescued death caused by AMPA, NMDA, and kainate as well as by buthionine sulfoximine (BSO) and ferrous chloride (Fe/sup 2+/) treatments. Furthermore, KBPTS promoted animal’s recovery from coma induced by a sublethal dose of KCN and improved survival by a lethal dose of KCN. To examine its physiological effects on the nervous system, we induced ischemia in the Sprague-Dawley rat’s brain by middle cerebral artery (MCA) occlusion. Neurological examination showed that KBPTS reduced the time which is required for the animal after MCA occlusion to respond in terms of forelimb and hindlimb movement$. Histological examination revealed that KBPTS reduced ischemic area and edema rate and also protected neurons in the cerebral cortex and hippocampus from ischemic damage. Thus, the present data suggest that KBPTS may play an important role in protecting neuronal cells from external noxious stimulations.
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KEYWORD
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Kami-bang-pung-tong-sung-san, neuron, neurotoxicity, middle cerebral artery (MCA) occlusion, hippocampus, cerebral cortex, rat
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